This book aims to guide using 3D modeling techniques, texturing, and assigning material by using healthcare as the core application for demonstration. Blender is a free and open-source digital content creation (DCC) tool that provides the freedom to users of different backgrounds to get started quickly. The demonstrating of healthcare application enables related expertise to be equipped with modeling and rendering techniques through understanding background knowledge in character modeling, dressing and animation in healthcare application. The target audience includes professionals and researchers working in virtual reality, computer graphics, computer simulation, design, visual arts in various disciplines, e.g., computer science, design, art, healthcare, rehabilitation, education, and information technology.