The book consists of three parts: The first one presents data in the framework of probability theory, exploratory data analysis, and unsupervised learning. The second part on inferential data analysis covers linear and logistic regression and regularization. The last part studies machine learning with a focus on support-vector machines and deep learning. Each chapter is based on a dataset, which can be downloaded from the book's homepage. In addition, the book has the following features: This book is for everyone who wants to understand and apply concepts and methods of statistical learning. Typical readers are graduate and advanced undergraduate students in data-intensive fields such as computer science, biology, psychology, business, and engineering, and graduates preparing for their job interviews.