This continuing series gathers and presents original research results on the leading edge of medicine and biology. Each article has been carefully selected in an attempt to present substantial topical data across a broad spectrum. Topics discussed in this book include central nervous system manifestations of TSC; methadone; dietary aspects, weight issues and bone health at and post-menopause; Stevens-Johnson syndrome and toxic epidermal necolysis; biosensors and their applications in healthcare; study on riboflavin encapsulation by cyclodextrins; thyroid goitres; anti-cyclic citrullinated peptide (anti-CCP) antibodies in different autoimmune diseases; and the role of flaxseed on non-alcoholic fatty liver disease (NAFLD) in rabbits submitted to a hypercholesterolemic diet.