The 164 papers presented were carefully reviewed and selected from 199 submissions. They discuss globally pressing issues in smart manufacturing, operations management, supply chain management, and Industry 4.0. The papers are organized in the following topical sections: Part I: advanced modelling, simulation and data analytics in production and supply networks; advanced, digital and smart manufacturing; digital and virtual quality management systems; cloud-manufacturing; cyber-physical production systems and digital twins; IIOT interoperability; supply chain planning and optimization; digital and smart supply chain management; intelligent logistics networks management; artificial intelligence and blockchain technologies in logistics and DSN; novel production planning and control approaches; machine learning and artificial intelligence; connected, smart factories of the future; manufacturing systems engineering: agile, flexible, reconfigurable; digital assistance systems: augmented reality and virtual reality; circular products design and engineering; circular, green, sustainable manufacturing; environmental and social lifecycle assessments; socio-cultural aspects in production systems; data-driven manufacturing and services operations management; product-service systems in DSN; and collaborative design and engineering Part II: the Operator 4.0: new physical and cognitive evolutionary paths; digital transformation approaches in production management; digital transformation for more sustainable supply chains; data-driven applications in smart manufacturing and logistics systems; data-driven services: characteristics, trends and applications; the future of lean thinking and practice; digital lean manufacturing andits emerging practices; new reconfigurable, flexible or agile production systems in the era of industry 4.0; operations management in engineer-to-order manufacturing; production management in food supply chains; gastronomic service system design; product and asset life cycle management in the circular economy; and production ramp-up strategies for product