This book constitutes the refereed proceedings of the 13th Annual International Symposium on Algorithms and Computation, ISAAC 2002, held in Vancouver, BC, Canada in November 2002. The 54 revised full papers presented together with 3 invited contributions were carefully reviewed and selected from close to 160 submissions. The papers cover all relevant topics in algorithmics and computation, in particular computational geometry, algorithms and data structures, approximation algorithms, randomized algorithms, graph drawing and graph algorithms, combinatorial optimization, computational biology, computational finance, cryptography, and parallel and distributedd algorithms.