Paul Dominick stop to assist at an accident on a desolate road, only to have one person bite him and another try to bash his brains in. Narrowly escaping with his life, he soon discovers that he isn't able to shake the victims of this accident from hounding him for his heroics. Changes develop from an infection passed on through an inadvertant transfusion of blood, which leaves him remarkably and irreversibly altered at the cellular level. As a paramedic, Dom has a difficult time adjusting to this change and thinks it's only his 24-hour shift that will suffer. It isn't long before he learns that no one wants to leave him alive in the condition he is.