Part I: Epidemiology, Biology, Genetics, and Pathology Epidemiology of Brain Tumors Randa El-Zein, Melissa Bondy, and Margaret Wrensch Molecular Genetics of Tumors of the Central Nervous System C. David James Molecular Pathology of Nervous System Tumors Catherine L. Nutt, Anat O. Stemmer-Rachamimov, J. Gregory Cairncross, and David N. Louis Genetic Modeling of Glioma Formation in Mice Martin Begemann, Vinagolu K. Rajasekhar, Gregory N. Fuller, and Eric C. Holland Biology of Brain Metastasis Minsoo Kang, Takamitsu Fujimaki, Seiji Yano, and Isaiah J. Fidler Analysis of Neural Precursor Cells in the Context of Origin of Brain Tumors, Their Treatment, and Repair of Treatment-Associated Damage Mark Noble and Joerg Dietrich Biology of Primitive Neuroectodermal Tumors John R. Hill, Shoichiro Ohta, and Mark A. Israel Part II: Mechanisms and Pathways Molecular and Cellular Biology of the Blood-Brain Barrier and Its Characteristics in Brain Tumors Helga E. de Vries, Lisette Montagne, Christine D. Dijkstra, and Paul van der Valk Immune Regulation in the Brain: Lessons From Autoimmunity and Implications for Brain Tumor Therapy Lois A. Lampson Genetic Pathways in the Evolution of Gliomas Hiroko Ohgaki and Paul Kleihues DNA Damage and Repair in the Therapeutic Response of Tumors of the Central Nervous System Henry S. Friedman, M. Eileen Dolan, and Francis Ali-Osman Role of Urokinase-Type Plasminogen Activator Receptor in Human Glioma Invasion Sanjeeva Mohanam and Jasti S. Rao Regulation of Cell Cycle and Apoptosis in Human Brain Tumors Juan Fueyo, Candelaria Gomez-Manzano, and Timothy J. McDonnell Part III: Therapeutics Systemic Chemotherapy for Metastatic Tumors of the Central Nervous System Charles A. Conrad and W. K. Alfred Yung Radiation Biology and Therapy of Tumors of the Central Nervous System Nalin Gupta, John R. Fike, Penny K. Sneed, Philip J. Tofilon, and Dennis F. Deen Advances in the Management of Cerebral Metastases Fadi Hanbali and Raymond Sawaya Immunotherapy of Central Nervous System Tumors: Contemporary Cancer Research Amy B. Heimberger, David A. Reardon, Darell D. Bigner, and John H. Sampson Targeting Drugs to Tumors of the Central Nervous System Maciej S. Lesniak, James Frazier, and Henry Brem Rational Design and Development of Targeted Brain Tumor Therapeutics Francis Ali-Osman, Henry S. Friedman, Gamil R. Antoun, David Reardon, Darell D. Bigner, and John K. Buolamwini Index