Head and neck cancer refers to a group of cancers that originate in the mouth, throat, sinuses, nose, larynx or salivary glands. Some of its common symptoms are a persistent sore throat, change in the voice, trouble swallowing and a lump or sore, which does not heal. Nearly 75% of all cases of head and neck cancer can be attributed to alcohol and tobacco consumption. Other risk factors include the consumption of betel quid, radiation exposure, Epstein-Barr virus, etc. Advancements in the diagnosis and local management of head and neck cancer and targeted therapy have resulted in the improvement in the quality of life and survival. Treatment generally follows a combination of radiation therapy, surgery, chemotherapy and targeted therapy. This book is a valuable compilation of topics, ranging from the basic to the most complex principles and practices in the management of cancer of the head and neck. It presents the complex subject of head and neck cancer in the most comprehensible language. The readers would gain knowledge that would broaden their perspective about this disease.