These multiple volumes (LNCS volumes 6016, 6017, 6018 and 6019) consist of the peer-reviewed papers from the 2010 International Conference on Compu- tional Science and Its Applications (ICCSA2010)held in Fukuoka, Japanduring March23-26,2010.ICCSA2010wasasuccessfuleventintheInternationalC- ferences on Computational Science and Its Applications (ICCSA) conference - ries, previouslyheld in Suwon, South Korea (2009), Perugia, Italy (2008), Kuala Lumpur, Malaysia (2007), Glasgow, UK (2006), Singapore (2005), Assisi, Italy (2004), Montreal, Canada (2003), and (as ICCS) Amsterdam, The Netherlands (2002) and San Francisco, USA (2001). Computational science is a main pillar of most of the present research, - dustrial and commercial activities and plays a unique role in exploiting ICT - novative technologies. The ICCSA conference series has been providing a venue to researchers and industry practitioners to discuss new ideas, to share complex problems and their solutions, and to shape new trends in computational science. ICCSA 2010 was celebrated at the host university, Kyushu Sangyo Univ- sity, Fukuoka, Japan, as part of the university's 50th anniversary.We would like to thank Kyushu Sangyo University for hosting ICCSA this year, and for - cluding this international event in their celebrations. Also for the ?rst time this year, ICCSA organized poster sessions that present on-going projects on various aspects of computational sciences.