This book constitutes the refereed proceedings of the 16th International Conference on Conceptual Structures, ICCS 2008, held in Toulouse, France, in July 2008. The 19 revised full papers presented together with 2 invited papers were carefully reviewed and selected from over 70 submissions. The scope of the contributions ranges from theoretical and methodological topics to implementation issues and applications. The papers present a family of Conceptual Structure approaches that build on techniques derived from artificial intelligence, knowledge representation, applied mathematics and lattice theory, computational linguistics, conceptual modeling, intelligent systems and knowledge management.