Drug abuse among youths in Africa has been a problem to the youths and the society in general. The consequences of drug abuse are not only on the individual user but also on his or her offspring, family and the society. This work is expected to create awareness, expose and provide useful information to people especially to the Nigerian youths on the effects of drug abuse and the challenges for the African churches towards drug abuse in Africa. Chapter one is an introductory chapter. It discusses the usefulness of drug in the life of a living thing and how it is being abused in Africa by the youths. The second chapter reviews the works of authors on drug abuse. The third chapter explains much about drug. There are a lot of substances like alcohol, cannabis, heroine etc and most of them were discussed including their abuses, uses, effects, causes of drug abuse etc. Chapter four discusses the challenges for the Nigerian churches on drug abuse in the Nigerian society. In this chapter, the researchers dwelt on what the church should do to control or stop drug abuse in Nigeria.