Lichen planus is a relatively common chronic inflammatory disease of oral mucosa and skin, whose exact pathogenic mechanisms have not been understood. Cortisol also called as "stress hormone", has been used as an indicator in various psychological evaluation studies. Salivary cortisol measurement is an indicator of free cortisol or biologically active cortisol in human serum and provides noninvasive and easy technique. Aims, Recent studies have been conflicting, and hence, in the present study, evaluation of cortisol levels and psycho-immunity profile in lichen planus patients was done. Using case-control method.