This book describes in a complete and consistent way an effective explanation to complex structures, systems, and components, and prescribes solutions to practical challenges. It reflects the scientific novelty and promises a feasible, workable, theoretical and applicative attitude. Earthquakes and Sustainable Infrastructure serves a “commentary role” for developers and designers of critical infrastructure and unique installations. Commentary-like roles follow standard, where there is no standard. Mega-installations embody/potentiate risks; nonetheless, lack a comprehensive classic standard. Every compound is unique, one of its kind, and differs from others even of similar function. There is no justification to elaborate a common standard for unique entities. On the other hand, these specific installations, for example, NPPs, Naval Ports, Suez Canal, HazMat production sites, and nuclear waste deposits, impose security and safety challenges to people and the environment. The book offers a benchmark for entrepreneurs, designers, constructors, and operators on how to compile diverse relevant information on site-effects and integrate it into the best-educated guess to keep safe and secure, people and environment. The authors are eager to convey the entire information and explanations to our readers, without missing either accurate information or explanations. That is achieved by “miniaturization,” as much is possible, not minimization. So far, the neodeterministic method has been successfully applied in numerous metropolitan areas and regions such as Delhi (India), Beijing (China), Naples (Italy), Algiers (Algeria), Cairo (Egypt), Santiago de Cuba (Cuba), Thessaloniki (Greece), South-East Asia (2004), Tohoku, Japan (2011), Albania (2019), Bangladesh, Iran, Sumatra, Ecuador, and elsewhere. Earthquakes and Sustainable Infrastructure includes case studies from these areas, as well as suggested applications to other seismically active areas around the globe. NDSHA approaches confirm/validate that science is looming to warn. Concurrently, leaders and practitioners have to learn to use rectified science in favor of peoples' safety. State-of-the-art science does have the know-how to reduce casualties and structural damage from potential catastrophes to a bearable incident.