The nuclear factor erythroid 2-related factor 2 (Nrf2) was described as a master regulator of the cellular antioxidant response. Moreover, many critical biological functions linked to cell viability, metabolism, autophagy, inflammation, immunity, and differentiation have been attributed to Nrf2, which regulates over 600 genes. It is well known that oxidative stress, which Nrf2 can ameliorate, plays a key role in many pathologic processes such as aging, obesity, diabetes, cancer, and neurodegenerative diseases.
Flavonoids, on the other hand, through their ability to activate and upregulate Nrf2, can have anti-oxidative, anti-inflammatory, anti-mutagenic, and anti-carcinogenic properties. Flavonoids are an essential ingredient in nutraceuticals, functional foods, and pharmaceuticals. The present book
Flavonoids and Anti-Aging: The Role of Transcription Factor Nuclear Erythroid 2-Related Factor2
focuses on the interaction between Nrf2 and flavonoids and their applications in various conditions such as aging, osteoporosis, cardiovascular diseases, and neurodegenerative disease and many other areas.
Key Features:
Focuses on the mechanisms and use of flavonoids in activating Nrf2 as an anti-aging and "WELLNESS" molecule
Provides a specific approach to flavonoid activation of Nrf2 and its implications in aging and various disease conditions and its applications as nutraceuticals
Presents flavonoid-based functional foods
Discusses the flavonoid nutraceuticals market and future trends
Written by experts in the field, this book provides a unique approach to understanding the flavonoid activation of the transcription factor Nrf2, which is responsible for many different disease conditions due to increased reactive oxidative species in the body caused by some physiological triggers.