Gap junction channels are a group of intercellular channels expressed in tissues and organs to synchronize many physiological processes. Pannexin channels are a family of closely related large-pore channels virtually unknown a decade ago. The field of connexin and pannexin research has recently exploded and became one of the most active areas of research. Numerous novel approaches and techniques have been developed, but there is no single book to dedicate on the unique techniques and protocols for the research on these large pore channels. The authors plan a book to focus on recent state-of-the-art techniques and protocols in various aspects of this diverse research field.