Famous radio private eye Guy Noir leaps from A Prairie Home Companion to the page On the 12th floor of the Acme Building, on a cold February day in St. Paul, Guy Noir looks down the barrel of a loaded revolver in the hands of geezer gangster Joey Roast Beef who is demanding to hear what lucrative scheme Guy is cooking up with stripper-turned-women's-studies-professor Naomi Fallopian. Everyone wants to know-Joey, Lieutenant McCafferty, reporter Gene Williker, Guy’s ex-girlfriend Sugar O'Toole, the despicable Larry B. Larry, the dreamboat Scarlett Anderson, Mr. Kress of the FDA–and Guy faces them one by one, as he and Naomi pursue a dream of earning gazillions by selling a surefire method of dramatic weight loss. In this whirlwind caper Guy faces danger, falls in love, and faces off with the capo del capo del grande primo capo Johnny Banana.