This practical guide contains seven modules targeted at district and health facility staff. It intends to meet the demands to improve immunization services so as to reach more infants in a sustainable way, building upon the experiences of polio eradication. It includes materials adapted from polio on planning, monitoring and use of data to improve the service, that can be used at any level.Revising the manual has been a team exercise. There are contributions from a large number of experts, organizations and institutions.This new edition has seven modules. Several new vaccines that have become more readily available and used in recent years have been added. Also the section on integration with other health interventions has been expanded as exciting opportunities and experiences have become evident in the years following the previous edition.Module 1: Target diseases and vaccinesModule 2: The vaccine cold chainModule 3: Ensuring safe injectionsModule 4: Microplanning for reaching every communityModule 5: Managing an immunization sessionModule 6: Monitoring and surveillanceModule 7: Partnering with communities.