This volume contains the proceedings of the International Conference on Inf- mation Computing and Applications (ICICA 2010), which was held in Tangshan, China, October 15-18, 2010. As future-generation information technology, information computing and applications become specialized, information computing and applications - cluding hardware, software, communications and networks are growing with ever-increasing scale and heterogeneity and becoming overly complex. The c- plexity is getting more critical along with the growing applications. To cope with the growing and computing complexity, information computing and applications focus on intelligent, selfmanageable, scalable computing systems and applications to the maximum extent possible without human intervention or guidance. With the rapid development of information science and technology, infor- tion computing has become the third approach of science research. Information computing and applications is the field of study concerned with constructing - telligent computing, mathematical models, numerical solution techniques and using computers to analyze and solve natural scientific, social scientific and engineering problems. In practical use, it is typically the application of c- puter simulation, intelligent computing, internet computing, pervasive comp- ing, scalable computing, trusted computing, autonomy-oriented computing, evolutionary computing, mobile computing, computational statistics, engine- ing computing, multimedia networking and computing, applications and other forms of computation problems in various scientific disciplines and engine- ing. Information computing and applications is an important underpinning for techniques used in information and computational science and there are many unresolvedproblems that address worth studying.