Our current situation, marked simultaneously by the Anthropocene, global warming, digitization and exponential artificial intelligence, leads us to sudden and total change in global civilization and, de facto, to rebuilding the foundations of the international economy. Innovation Ecosystems explores the risks and opportunities facing the contemporary world by analyzing, comparing and categorizing the world’s most dynamic innovation ecosystems by region and city. This includes the identification of key characteristics – common or original – and learning from them in terms of culture, management, system and structure, in order to meet current challenges and think about civilizations of the future.