The book explains that this requires business-oriented thinking and acting from IT specialists and data scientists. It is a good idea to let students experience this directly from the business perspective, for example as executives of a virtual company in a role-playing game. The second edition of the book has been completely revised, restructured and supplemented with actual topics such as blockchains in supply chains and the correlation between Big Data analytics, artificial intelligence and machine learning. The structure of the book is based on the gradual implementation and integration of the respective information systems from the business and management perspectives. Part I contains chapters with detailed descriptions of the topics supplemented by online tests and exercises. Part II introduces role play and the online gaming and simulation environment. Supplementary teaching material, presentations, templates, and video clips are available online in the gaming area.