This book aims at providing an introduction by illustrating state-of-the-art security challenges and threats in IoT and the latest developments in IoT with Cloud, AI, and Blockchain security challenges. Various application case studies from domains such as science, engineering, and healthcare are introduced, along with their architecture and how they leverage various technologies Cloud, AI, and Blockchain. This book provides a comprehensive guide to researchers and students to design IoT integrated AI, Cloud, and Blockchain projects and to have an overview of the next generation challenges that may arise in the coming years.