Iron neurodegeneration research has grown tremendously over the last few decades, and this progress has been documented in numerous articles. However, few publications focus specifically on brain iron overload and the overexpression of Alzheimer's amyloid precursor protein through Iron Responsive Element (IRE) regulatory pathways, despite the many compilations covering topics related to iron metabolism and Alzheimer's disease. Deciphering the complex mechanisms of amyloid aggregation and IRE signaling pathways is essential to understanding the mysteries of Alzheimer's progression. This book, Iron Neurodegeneration, explains in detail how iron metabolism is regulated and how it affects the development of neurodegenerative diseases. The primary goal is to explore how amyloid aggregates via IRE mRNA translation and identify potential therapeutic targets for neurodegenerative conditions. This book is intended for a broad readership: expert professionals will appreciate the in-depth descriptions and discussions, while students, researchers, and scientists new to the subject will benefit from the comprehensive introduction that provides a strong intellectual foundation.