This issue of the Journal of Latin American Theology is dedicated to the memory of C. Rene Padilla (1932-2021). In "The Life and Legacy of C. Rene Padilla," historian Daniel Salinas presents the essential events of Rene's life and ministry. In 2008, Darren C. Marks published Rene's own account of his theological journey in Shaping a Global Theological Mind. We are grateful to reprint "My Theological Pilgrimage," in which Rene described the factors that contributed to his development as a theologian and practitioner. Next, the five children Rene had with his late wife Catharine Feser Padilla offer a heartfelt overview of their father's life. A sample of tributes from friends and family members then describes not only Rene's writings and mental brilliance but also his humility, hospitality, courage, and gentleness as a mentor. And the three poets included herein give testimony to Rene's unflagging dedication to encouraging and publishing other writers across the genres. Next, historian Dinorah Mendez reviews Rene's last literary venture, Raices de un evangelio integral: mision en perspectiva historica and demonstrates that the primary theological emphasis of Rene's life--mision integral--has been practiced by the people of God in their various contexts throughout history. Finally, with the combined efforts of several scholars, we have compiled as complete a bibliography of Rene's published works as possible.