This book gathers selected papers presented at the International Conference on Machine Intelligence and Soft Computing (ICMISC 2021), organized by Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India during 22 – 24 September 2021. The topics covered in the book include the artificial neural networks and fuzzy logic, cloud computing, evolutionary algorithms and computation, machine learning, metaheuristics and swarm intelligence, neuro-fuzzy system, soft computing and decision support systems, soft computing applications in actuarial science, soft computing for database deadlock resolution, soft computing methods in engineering, and support vector machine.