This volume contains results of the German CFD initiative MEGADESIGN which combines CFD development activities from DLR, universities and aircraft industry. Based on the DLR flow solvers FLOWer and TAU the main objectives of the four-years project is to ensure the prediction accuracy with a guaranteed error bandwidth for certain aircraft configurations at design conditions, to reduce the simulation turn-around time for large-scale applications significantly, to improve the reliability of the flow solvers for full aircraft configurations in the complete flight regime, to extend the flow solvers to allow for multidisciplinary simulations and to establish numerical shape optimization as a vital tool within the aircraft design process. This volume highlights recent improvements and enhancements of the flow solvers as well as new developments with respect to aerodynamic and multidisciplinary shape optimization. Improved numerical simulation capabilities are demonstrated by several industrial applications.