Mihondria, often referred to as the “powerhouses” of the cell, generate adenosine triphosphate (ATP) by oxidative phosphorylation or OXPHOS, and maintain cellular homeostasis. In addition to generating ATP, mihondria are involved in regulation of cell cycle, proliferation, free radical production, innate immune responses and apoptosis.
Mihondrial Function in Lung Health and Disease
fills the current gap in the literature and outlines the growing clinical relevance of mihondrial dysfunction. Currently, there is no overview on the role of mihondria in pulmonary diseases and this volume focuses on the mihondrial metabolism, redox signaling, and mechanisms of mihondrial pathways in lung injury, inflammation, repair and remodeling. Furthermore, in addition to their well-recognized role in cellular energy production and apoptosis, mihondria appear to play a role in many respiratory diseases and lung cancer. Chapters are written by top notch researchers and clinicians and outline the evidence for mihondrial biogenesis in inhalational lung injury, COPD and asthma.