Preface 1. The origin of cancer, Evan Y. Yu and William C. Hahn 2. The pathology of thyroid cancer; Sylvia L. Asa 3. Thyroid lymphomas; Runjan Chetty 4. Molecular events in follicular thyroid tumors; Todd G. Kroll 5. Molecular epidemiology of thyroid cancer; Martin Schlumberger 6. Growth factors and their receptors in the genesis and treatment of thyroid cancer; Shereen Ezzat 7. Biology of Ras in thyroid cells; Judy L. Meinkoth 8. P53 and other cell cycle regulators; Nadir R. Farid 9. Abnormalities of nuclear receptors in thyroid cancer; Sheue-Yann Cheng 10. Matrix metalloproteinases in thyroid cancer; Yufei Shi and Minjing Zou 11. The molecular pathways induced by radiation and leading to thyroid carcinogenesis; Yuri E. Nikiforov 12. TRK oncogenes in papillary thyroid carcinoma; Angela Greco, Emanuela Roccato and Marco A. Pierotti 13. Thyroidal iodide transport and thyroid cancer; Orsolya Dohán and Nancy Carrasco 14. Molecular signaling in thyroid cancer; Nicholas J. Sarlis and Salvatore Benvenga 15. Gene expression in thyroid tumors; Laszlo Puskas and Nadir R. Farid 16. Animal models of thyroid carcinogenesis; Carsten Boltze 17. Diagnostic molecular markers in thyroid cancer; Matthew D. Ringel 18. Thyroid cancer imaging; T.T.H. Phan, P.L. Jager, K.M. van Tol, T.P. Links 19. Past, presence and future of thyroid-stimulating hormone (TSH) superactive analogs; Mariusz W. Szkudlinski 20. Pathobiology of antineoplastic therapy in undifferentiated thyroid cancer; Kenneth B. Ain 21. Gene therapy for thyroid cancer; Yuji Nagayama 22. Familial papillary thyroid carcinoma; Carl D. Malchoff and Diana M. Malchoff 23. RET activation in medullary carcinomas; Marco A. Pierotti, Elena Arighi, Debora Degl'Innocenti and Maria Grazia Borrello 24. From genes to decisions; Lois M. Mulligan