Pb is an ancient metal that has multiple industrial uses, but when it is manipulated and present in living organisms such as humans, it has serious pathological effects on systems, organs and tissues, the amount in the body will be proportional to the toxic severity. The objective of this work is to update the knowledge on the occupational implications of Pb exposure and its damage to health in different geographical areas. This metal is present in some occupational activities and in the environment in general. The absorption of this mineral depends on the degree of occupational and environmental exposure in men and women. Monitoring by health areas is essential for detection, early prevention and treatment of people affected by the environment, food or occupational handling. Its determination is by means of a venous blood sample, which helps to determine risk levels of exposure to Pb in blood ≥10 µg/dl. At high levels, Pb in the body causes permanent damage to the brain and CNS. This damage can lead to seizures, loss of muscle control and coma.