Start-up ecosystems have sprung up all over the world, but the original is still number one, in terms of access to talent and capital. Silicon Valley has developed its own culture that emphasizes openness and break-through innovation and inspires start-up scenes around the world. The vibe is not for everyone and of course there are challenges, such as the high cost of housing and office space, but between 14,000 and 19,000 start-ups have now settled here. More than half of the entrepreneurs come from around the world, so it makes no difference where in the world you are right now. A good idea is always welcome here - and has a chance of success, provided you play your cards right. In much the same way, learning the essentials of building a start-up as well as profiting from others experiences, is the reason we've conducted these interviews and assembled them in this book. The book is divided into four overarching sections. The first section focuses on the ecosystem on which a successful start-up is based. Silicon Valley has been recognized as the flagship-ecosystem - not only for co-location of large and high-profile technology companies like Google, Apple, and Facebook, but also for the clustering of entrepreneurs, venture capitalists, research institutes, and support infrastructure. In the second section, you will learn about the business, financial and legal foundation that needs to be established when setting up a start-up. In the third part we discuss mega growth mega market opportunities at hand: Cybersecurity, nanotechnology, biosensors, printed sensors, Block chain, Wave energy, Cannabis etc. The fourth and final part you will dive into the success stories of well-known companies, as well as start-ups that have the potential to become the next Unicorns.