The big question of how and why mindedness evolved necessitates collaborative, multidisciplinary investigation. Biosemiotics provides a new conceptual space that attracts a multitude of thinkers in the biological and cognitive sciences and the humanities who recognize continuity in the biosphere from the simplest to the most complex organisms, and who are united in the project of trying to account for even language and human consciousness in this comprehensive picture of life. The young interdiscipline of biosemiotics has so far by and large focused on codes, signs and sign processes in the microworld—a fact that reflects the field’s strong representation in microbiology and embryology. What philosophers of mind and cognitive scientists can contribute to the growing interdiscipline are insights into how the biosemiotic weltanschauung applies to complex organisms like humans where such signs and sign processes constitute human society and culture.