In 1921, Gene Ahern created the comic strip Crazy Quilt, starring the Nut Brothers, Ches and Wal. That same year, NEA General Manager Frank Rostock suggested to Ahern that he use a boarding house for a setting. Ahern initially used his own experiences as a boarder while a Chicago, Illinois, art student as grist for his comic mill, and featured the picaresque peccadilloes and bickering of its residents, presided over by the no-nonsense Martha Hoople. Our Boarding House began September 16, 1921, scoring success with readers after the January 1922 arrival of the fustian, blustery Major Amos B. Hoople, Martha's husband, who'd returned after some long sojourn. "Hoople has been compared to the type created on-screen by W. C. Fields, but was probably closer to Falstaff," writes comics historian Maurice Horn. "A retired military man of dubious achievement like Shakespeare's, he boasted of soldierly exploits that were perhaps not all invented, and his buffoonery sometimes concealed real pathos." That character depth diminished as the comic became more popular, with Major Hoople becoming "the one-dimensional figure of fun most people remember" of the strip. The primary boarders were the cynical Clyde and Mack, and the only somewhat more trusting Buster.
According to comics historian Allan Holtz, a multi-panel Sunday strip was added on December 31, 1922. Starting from October 25, 1931, Ahern's The Nut Bros, featuring loony siblings Ches and Wal in pun-filled, vaudevillian bits of business, ran as a topper strip.