This volume introduces an innovative tool for the development of sustainable cities and the promotion of the quality of life of city inhabitants. It presents a decision-support system to orient public administrations in identifying development scenarios for sustainable urban and territorial transformations. The authors have split the volume into five parts, which respectively describe the theoretical basis of the book, the policies in question and indicators that influence them, the decision-support system that connects indicators to policies, the case study of Ancona, Italy, and potential future directions for this work.