As Nobel Laureate physicist Philip W. Anderson realized, the key to understanding nature’s reality is not anything “magical”, but the right attitude, “the focus on asking the right questions, the willingness to try (and to discard) unconventional answers, the sensitive ear for phoniness, self-deception, bombast, and conventional but unproven assumptions.” The authors of the eighteen prize-winning essays have, where necessary, adapted their essays for the present volume so as to (a) incorporate the community feedback generated in the online discussion of the essays, (b) add new material that has come to light since their completion and (c) to ensure accessibility to a broad audience of readers with a basic grounding in physics. The Foundational Questions Institute, FQXi, catalyzes, supports, and disseminates research on questions at the foundations of physics and cosmology, particularly new frontiers and innovative ideas integral to a deep understanding of reality, but unlikely to be supported by conventional funding sources.