Special Agent Leon S. Kennedy comes face-to-face with a nightmare he may never be able to escape as the terrifying Resident Evil saga continues. Convinced that Bio Organic Weapons (B.O.W.s) are being used in combat, Leon infiltrates a secluded Eastern European seeking the evidence he needs to confirm the rumors. As soon as Leon crosses the border, however, his contacts in the U.S. order him to abort his mission immediately. But he's come too far to simply turn his back now, and as Leon vows to neutralize the threat of B.O.W.s once and for all, the Umbrella Corporation's most dangerous weapon threatens to unleash a literal hell on earth.