There's something very wrong occurring on a tiny island located off the coastline of Louisiana. An Island whose only building, an ages old fortress ... which was converted years ago into a prison hospital for the criminally insane. Paranormal Investigator Ian McDermott has come to New Orleans to investigate Haitian Voodoo and Zombiism. Unwittingly he teams up with a mysterious man known only as, Mr. E. Together their investigations lead them to the island of the insane, where they come face to face with an evil that if they cannot dispatch ... could unleash the SCHIZOMEGA effect ... spelling doom for us all.