This book comprises the proceedings of the International Perm Forum “Science and Global Challenges of the 21st Century” held on October 18th – 23rd, 2021, at Perm State University, Perm, Russia. Global challenges, which determine the main trends in the development of social and economic life in the XXI century, require the integration of specialists in various fields of knowledge. That is why the main principle of this edition is interdisciplinarity, the formation of end-to-end innovation chains, including fundamental and applied research, and the wide application of smart innovations, networks, and information technologies.