The intention of this book is to provide a comprehensive and contemporary review of the biology of sensory nerves. In keeping with the theme of the Handbook series, an emphasis will be placed on the actions of drugs, transmitters and autacoids that initiate or inhibit sensory nerve activation (through actions on ion channels and receptors at their peripheral terminals) or modulate the release or actions of the transmitters released from the central terminals of sensory nerves. Based on extensive supportive evidence in the literature, it is our view that many diseases are characterised by alterations in sensory nerve function (eg pain, cardiovascular disease, and migraine). It is our belief that this book will be unique, as it will comprehensively cover the role of sensory nerves across many therapeutic areas.