This innovative textbook reconfigures generalist social work practice for the twenty-first century. Incorporating historical, ethical, and global perspectives, the volume presents new conceptualizations, definitions, and explanations for social work practice and principles in the areas of assessment, relationships, communication, best practices, intervention, and differential use of self. Case studies fully discuss and illustrate the use of these approaches with real clients and provide a lens inclusive of geography and culture to promote social justice and human well-being, whether within one's own nation or across national borders. Recognizing that targeted practice with individuals is the key to successful outcomes, this textbook equips today's practitioners with the values, skills, and knowledge necessary for social work practice in a globalized world.