Systems biology is the modeling of biological systems by integrating the principles of computer science and mathematics. Bioinformatics and systems biology are interrelated fields, which are concerned with the construction of biological software and methods to compute biological data. Such systems of computation are called biological computers that use biological databases for use in multiple fields such as bioengineering, biotechnology, etc. This book aims to present the fundamental concepts and theories central to the fields of systems biology and bioinformatics in comprehensive detail. The objective of this book is to give a general view of different areas of these fields and their applications. It presents researches and studies performed by experts across the globe. For someone with an interest and eye for detail, this book covers the most significant topics in the fields of systems biology and bioinformatics.