Fabien Levesque has endured intense suffering since his maker and ex-lover, Stefan, turned him into a vampire. The nightmare continues as the vengeful voodoo high-priestess Raphaella seeks retribution.
Together, their formidable evil allows Stefan to possess the body of Fabien's lover, Laurent Richelieu. Forced to flee the city and the man he loves, Fabien leaves New Orleans and finds refuge in San Francisco, where he crosses paths with the enigmatic vampire royalty, whose motives are as mysterious as their power, and a renowned deadly vampire hunter, whose skills are as lethal as his reputation.
The path to united vengeance becomes clear as Fabien discovers his powerful allies share his desire to conquer Stefan. Yet, the challenge remains: persuading Raphaella to use her voodoo magic to free Stefan's spirit from Laurent's body.
If he fails, mortals everywhere will become innocent victims of Stefan's unrelenting blood lust, his insatiable hunger for human life leading to a massacre of unimaginable proportions. Soon, his army of vampires, a relentless force of darkness and death, will destroy all of humanity, plunging the world into eternal night.