Using case studies and examples of geospatial analyses, this volume adopts a geographic lens to highlight the differences and commonalities across space and time where fundamental inequities are exposed, the governmental response is varied, and outcomes remain uncertain. This moment of global collective experience starkly reveals how inequality is ubiquitous and vulnerable populations – those unable to access basic needs – are increasing. This place-based approach identifies how geospatial analyses and resulting maps depict the pandemic as it ebbs and flows across the globe. Data-driven decision making is needed as we navigate the pandemic and determine ways to address future such events to enable local and regional governments in prioritizing limited resources to mitigate the long-term consequences of COVID-19.