The aim of this book, The Innate Immune System in Health and Disease: From the Lab Bench Work to Its Clinical Implications. Volume 1, is to provide updated information to scientists and clinicians that is valuable in their quest to gather information, carry out new investigations, and develop novel drugs that are more effective and do not cause adverse effects targeting the innate immune system. This book is of high priority to people interested in an update on innate immunity. Volume 1 examines the participation of innate immunity in diseases such as infections by viruses, cancer, or parasites. Specifically, this volume discusses innate immunity as it relates to chronic HIV infection, type 2 diabetes, and SARS-CoV-2, as well as its relationship with vitamin D. The dual role of neutrophils in cancer development and the plasticity of natural killer cells are investigated. Also, the immune response to infections from helminth and Toxoplasma gondii are described. The Innate Immune System in Health and Disease: From the Lab Bench Work to its Clinical Implications. Volume 1 promises to be a must-have book for all people who want to know about the role of the basic functioning of the innate immune system in several diseases of actual relevance to human health.