Answers to these questions and more are pursued every week on Premiering in November 2004, the darkly quirky medical drama introduced a compelling new character to prime-time television: the sarcastic, abrasive—and brilliant—Dr. Gregory House. Week after week, has held viewers’ attention with brilliant cast performances and intriguing diagnostic mysteries often solved with daring treatments. But how much of the medical detail is real and how much is fabricated? In , Andrew Holtz, a well-known medical journalist, reveals how medical detectives work—how they follow symptoms to their source. He examines each case in detail—and provides answers for every viewer who has ever wondered about the authenticity of their favorite show.