Angela (Olivia Taylor Dudley), a beautiful but ordinary young woman, begins to exhibit strange behaviors that seem to coincide with terrible tragedies involving anyone close to her. When demonic possession is suspected the Vatican is called upon to perform an exorcism that quickly proves to be no match for the ancient satanic force inhabiting Angela's body. Realizing the entire world is in jeopardy, Father Lozano (Michael Pe?a) is brought in to wage war for Angela's soul and for life as we know it.