The book is naturally divided into three parts. The first part of the book presents recent advances in theoretical and computational aspects of VEMs, discussing the generality of the meshes suitable to the VEM, the implementation of the VEM for linear and nonlinear PDEs, and the construction of discrete hessian complexes. The second part of the volume discusses Virtual Element discretization of paradigmatic linear and non-linear partial differential problems from computational mechanics, fluid dynamics, and wave propagation phenomena. Finally, the third part contains challenging applications such as the modeling of materials with fractures, magneto-hydrodynamics phenomena and contact solid mechanics. The book is intended for graduate students and researchers in mathematics and engineering fields, interested in learning novel numerical techniques for the solution of partial differential equations. It may as well serve as useful reference material for numerical analysts practitioners of the field.