Transporters in Drug Development
examines how membrane transporters can be dealt with in academic–industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of
in vitro
characterization of single transporters in the intestines, liver and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters’ impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating
observed interaction of transporters into
in vivo
relevance are explored, and the book highlights perspectives of applying targeted proteomics and mechanistic modeling in this process.