This volume contains the proceedings of the 11th International Conference on Verification, Model Checking, and Abstract Interpretation (VMCAI 2010), held in Madrid, Spain, January 17–19, 2010. VMCAI 2010 was the 11th in a series of meetings. Previous meetings were held in Port Jefferson (1997), Pisa (1998), Venice (2002), New York (2003), Venice (2004), Paris (2005), Charleston (2006), Nice (2007), San Francisco (2008), and Savannah (2009). VMCAI centers on state-of-the-art research relevant to analysis of programs and systems and drawn from three research communities: verification, model checking, and abstract interpretation. A goal is to facilitate interaction, cro- fertilization, and the advance of hybrid methods that combine two or all three areas. Topics covered by VMCAI include program verification, program cert- cation, model checking, debugging techniques, abstract interpretation, abstract domains, static analysis, type systems, deductive methods, and optimization. The Program Committee selected 21 papers out of 57 submissions based on anonymous reviews and discussions in an electronic Program Committee me- ing. The principal selection criteria were relevance and quality.