A year has passed since teen witch, Isis Rivera, teen magician, Zack Galloway, and Isis' Wiccan family survived the war which spanned time and alternate realities. They now live a peaceful existence in the comforts of New Salem, a hidden sanctuary for witches. However, a return trip to the Vegas strip for a Witches of Vegas reunion show leads to more than the family bargained for. Zack is abducted through supernatural means and Isis finds herself the prime suspect of a murder. These events coincide with the arrival of an enemy from a history that no longer exists, who is on a mission that will lead to the end of the world. It will take the combined efforts of The Witches of Vegas and New Salem's Task Force to save every single life on Earth. Luckily, they have a plan. Enter Harry, a boy from the future who will be Earth's last surviving human. He has come back in time to let everyone know that their plan to save the world, and all life on it, won't work. How can The Witches of Vegas win when they are destined to lose?